1,092 research outputs found
Active optical clock based on four-level quantum system
Active optical clock, a new conception of atomic clock, has been proposed
recently. In this report, we propose a scheme of active optical clock based on
four-level quantum system. The final accuracy and stability of two-level
quantum system are limited by second-order Doppler shift of thermal atomic
beam. To three-level quantum system, they are mainly limited by light shift of
pumping laser field. These limitations can be avoided effectively by applying
the scheme proposed here. Rubidium atom four-level quantum system, as a typical
example, is discussed in this paper. The population inversion between
and states can be built up at a time scale of s.
With the mechanism of active optical clock, in which the cavity mode linewidth
is much wider than that of the laser gain profile, it can output a laser with
quantum-limited linewidth narrower than 1 Hz in theory. An experimental
configuration is designed to realize this active optical clock.Comment: 5 page
Natural Phenolic Acids and Their Derivatives against Human Viral Infections
Natural compounds with structural diversity and complexity offer a great chance to find new antiviral agents. Phenolic acids have attracted considerable attention due to their potent antiviral abilities and unique mechanisms. The aim of this review is to report new discoveries and update pertaining to antiviral phenolic acids. The antiviral phenolic acids were classified according to their structural properties and antiviral types. Meanwhile, the antiviral characteristics and structure-activity relationships of phenolic acids and their derivatives were summarized. Natural phenolic acids and their derivatives possess potent inhibitory effects on multiple viruses in humans such as human immunodeficiency virus, hepatitis C virus, hepatitis B virus, herpes simplex virus, influenza virus and respiratory syncytial virus etc. In particular, caffeic acid/gallic acid and their derivatives exhibit outstanding antiviral properties through a variety of modes of action. In conclusion, naturally derived phenolic acids especially caffeic acid/gallic acid and their derivatives may be regarded as novel promising antiviral leads or candidates. Additionally, scarcely any of these compounds have been used as antiviral treatments in clinical practice. Therefore, these phenolic acids with diverse skeletons and mechanisms provide us an excellent resource for finding novel antiviral drugs
Reducing electronic transport dimension to topological hinge states by increasing geometry size of Dirac semimetal Josephson junctions
The notion of topological phases has been extended to higher-order and has
been generalized to different dimensions. As a paradigm, Cd3As2 is predicted to
be a higher-order topological semimetal, possessing three-dimensional (3D) bulk
Dirac fermions, two-dimensional (2D) Fermi arcs, and one-dimensional (1D) hinge
states. These topological states have different characteristic length scales in
electronic transport, allowing to distinguish their properties when changing
sample size. Here, we report an anomalous dimensional reduction of supercurrent
transport by increasing the size of Dirac semimetal Cd3As2-based Josephson
junctions. An evolution of the supercurrent quantum interferences from a
standard Fraunhofer pattern to a superconducting quantum interference device
(SQUID)-like one is observed when the junction channel length is increased. The
SQUID-like interference pattern indicates the supercurrent flowing through the
1D hinges. The identification of 1D hinge states should be valuable for deeper
understanding the higher-order topological phase in a 3D Dirac semimetal
Disparities and risks of sexually transmissible infections among men who have sex with men in China: a meta-analysis and data synthesis.
BACKGROUND: Sexually transmitted infections (STIs), including Hepatitis B and C virus, are emerging public health risks in China, especially among men who have sex with men (MSM). This study aims to assess the magnitude and risks of STIs among Chinese MSM. METHODS: Chinese and English peer-reviewed articles were searched in five electronic databases from January 2000 to February 2013. Pooled prevalence estimates for each STI infection were calculated using meta-analysis. Infection risks of STIs in MSM, HIV-positive MSM and male sex workers (MSW) were obtained. This review followed the PRISMA guidelines and was registered in PROSPERO. RESULTS: Eighty-eight articles (11 in English and 77 in Chinese) investigating 35,203 MSM in 28 provinces were included in this review. The prevalence levels of STIs among MSM were 6.3% (95% CI: 3.5-11.0%) for chlamydia, 1.5% (0.7-2.9%) for genital wart, 1.9% (1.3-2.7%) for gonorrhoea, 8.9% (7.8-10.2%) for hepatitis B (HBV), 1.2% (1.0-1.6%) for hepatitis C (HCV), 66.3% (57.4-74.1%) for human papillomavirus (HPV), 10.6% (6.2-17.6%) for herpes simplex virus (HSV-2) and 4.3% (3.2-5.8%) for Ureaplasma urealyticum. HIV-positive MSM have consistently higher odds of all these infections than the broader MSM population. As a subgroup of MSM, MSW were 2.5 (1.4-4.7), 5.7 (2.7-12.3), and 2.2 (1.4-3.7) times more likely to be infected with chlamydia, gonorrhoea and HCV than the broader MSM population, respectively. CONCLUSION: Prevalence levels of STIs among MSW were significantly higher than the broader MSM population. Co-infection of HIV and STIs were prevalent among Chinese MSM. Integration of HIV and STIs healthcare and surveillance systems is essential in providing effective HIV/STIs preventive measures and treatments. TRIAL REGISTRATION: PROSPERO NO: CRD42013003721
Observation of a ppb mass threshoud enhancement in \psi^\prime\to\pi^+\pi^-J/\psi(J/\psi\to\gamma p\bar{p}) decay
The decay channel
is studied using a sample of events collected
by the BESIII experiment at BEPCII. A strong enhancement at threshold is
observed in the invariant mass spectrum. The enhancement can be fit
with an -wave Breit-Wigner resonance function with a resulting peak mass of
and a
narrow width that is at the 90% confidence level.
These results are consistent with published BESII results. These mass and width
values do not match with those of any known meson resonance.Comment: 5 pages, 3 figures, submitted to Chinese Physics
A side-by-side comparison of Daya Bay antineutrino detectors
The Daya Bay Reactor Neutrino Experiment is designed to determine precisely
the neutrino mixing angle with a sensitivity better than 0.01 in
the parameter sin at the 90% confidence level. To achieve this
goal, the collaboration will build eight functionally identical antineutrino
detectors. The first two detectors have been constructed, installed and
commissioned in Experimental Hall 1, with steady data-taking beginning
September 23, 2011. A comparison of the data collected over the subsequent
three months indicates that the detectors are functionally identical, and that
detector-related systematic uncertainties exceed requirements.Comment: 24 pages, 36 figure
A Unified Approach to the Classical Statistical Analysis of Small Signals
We give a classical confidence belt construction which unifies the treatment
of upper confidence limits for null results and two-sided confidence intervals
for non-null results. The unified treatment solves a problem (apparently not
previously recognized) that the choice of upper limit or two-sided intervals
leads to intervals which are not confidence intervals if the choice is based on
the data. We apply the construction to two related problems which have recently
been a battle-ground between classical and Bayesian statistics: Poisson
processes with background, and Gaussian errors with a bounded physical region.
In contrast with the usual classical construction for upper limits, our
construction avoids unphysical confidence intervals. In contrast with some
popular Bayesian intervals, our intervals eliminate conservatism (frequentist
coverage greater than the stated confidence) in the Gaussian case and reduce it
to a level dictated by discreteness in the Poisson case. We generalize the
method in order to apply it to analysis of experiments searching for neutrino
oscillations. We show that this technique both gives correct coverage and is
powerful, while other classical techniques that have been used by neutrino
oscillation search experiments fail one or both of these criteria.Comment: 40 pages, 15 figures. Changes 15-Dec-99 to agree more closely with
published version. A few small changes, plus the two substantive changes we
made in proof back in 1998: 1) The definition of "sensitivity" in Sec. V(C).
It was inconsistent with our actual definition in Sec. VI. 2) "Note added in
proof" at end of the Conclusio
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